Национальный
институт фтизиатрии и пульмонологии
имени Ф.Г. Яновского

Украинский химиотерапевтический журнал

Об институте:

история,

общие положения,

структура,

научная деятельность,

планы НИР,

лечебно-диагностическая работа,

ведущие ученые

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новинки на сайте

Наши издания:

"Украинский пульмонологический журнал" (УПЖ),
"Украинский химиотерапевтический журнал" (УХЖ),
"Астма и аллергия"

Оригинальные статьи:

оригинальные научные статьи, ранее нигде не публиковавшиеся

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методические рекомендации, информационные письма,
ведомственные инструкции,
нововведения, монографии

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патенты и авторские свидетельства института

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рефераты законченных научно-исследовательских работ

Подготовка кадров:

аспирантура,

клиническая ординатура,
курсы информации и стажировки,

в помощь аспиранту и соискателю

Научные форумы:

резолюции и обращения съездов, конференций, совещаний...

Информация для специалистов:

обзоры литературы, статистическая информация, новое в лечении туберкулеза и неспецифических заболеваний легких...

Информация для населения:

полезная информация о заболеваниях легких, их профилактике и лечении

Ukrainian Journal of Chemotherapy.- 2005.- № 1-2.
Abstracts

L.A. Golik, L.V. Veselovskiy, A.R. Sapodgnikov
ACTUAL POINTS ON ORGANIZATION OF PHTHISIOLOGY SERVICE AND ANTITUBERCULOSIS ACTIONS IN ARMED FORCES OF UKRAINE // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 5-7
Summary. Questions about diagnostic, treatment and prophylaxis of tuberculosis, clinical examination and rehabilitation of patients in Armed Forces of Ukraine are view in article.
Key words: tuberculosis, diagnostic, treatment, prophylaxis, clinical examination, rehabilitation.

N.M. Shuba, T.D. Voronova, J.V. Kartashova
LEVOFLOXACIN IN THE SEQUENTIAL THERAPY OF PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 8-12
Summary. In the article the review of literature and results of our clinical researches of the sequential therapy by levofloxacin for treatment of community-acquired pneumonia are presented.
Keywords: community-acquired pneumonia, antibacterial therapy, sequential therapy, fluoroquinolones, levofloxacin.

V.M. Petrenko, N.A. Litvinenko
EFFICACY OF STANDARD ANTIBACTERIAL REGIMEN IN CASES OF FIRST-DIAGNOSED DESTRUCTIVE LUNG TUBERCULOSIS WITH BACTERIOEXCRETION // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 13-20
Summary. Data from publications and our observations with information about efficacy of standardized chemotherapy in cases of first-diagnosed destructive lung tuberculosis with excretion of Mycobacterium tuberculosis, in particular about controlled short-course therapy (DOTS) of this patients in Ukraine and Russia. We made conclusion that efficacy of standardized chemotherapy in cases of first-diagnosed destructive lung tuberculosis with excretion of Mycobacterium tuberculosis depend on intensity of chemotherapy, number and dimension of cavities. This factors will be taken into account when new standards of therapy will be created.
Key words: destructive tuberculosis, standards of therapy, DOTS, and dimensions of cavities, efficacy of therapy.

О.S. Bondaruk, О.V. Ponomareva, G.I. Klimnjuk
INFECTION COMPLICATIONS OF CYTOSTATYC THERAPY, PREVENTION AND MANAGEMENT // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 21-25
Summary. The modern status of febrile neutropenia's management for patients with malignant tumors is reviewed. The principles of antimicrobial, antifungal and antiviral therapy are considered, as more as combination of different drug and requirements for there usage.
Key words: febrile neutropenia, antiinfectious chemotherapy.

G.B. Kapitan, O.Ya. Dzyublyk, N.M. Nedlinska, V.G. Slabchenko, O.O. Mukhin, V.Ya. Klyahin, R.E. Sukhin, O.J. Byalik,S.S. Simonov, S.M. Prokopchuk, V.V. Lodgkin PREVALENCE AND MAIN RISK-FACTORS OF HOSPITAL-ACQUIRED PNEUMONIA IN PATIENTS OF MULTIDIVISIONAL HOSPITAL
// Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 26-29
G.B. Kapitan, O.Ya. Dzyublyk, N.M. Nedlinska, V.G. Slabchenko, O.O. Mukhin, V.Ya. Klyahin, R.E. Sukhin, O.J. Byalik,S.S. Simonov, S.M. Prokopchuk, V.V. Lodgkin
Summary. By the results of expert assessment of 9852 in-patients case reports prevalence of hospital-acquired pneumonia (HAP) in patients of multidivisional hospital is 0,4–2,5% between all patients and 12,1–37,5% between death cases (accordingly 0,7 and 18,5% average). Most significant risk-factors of HAP were identified: treatment of patients in ICU (in 82,1%), antibacterial therapy in forego period (in 76,8%), carrying of artificial pulmonary ventilation (in 71,4%), surgery (in 71,4%), declining years (in 60,7%), severe main disease with functional insufficiency of organs and systems (in 58,9%). Received dates will give in future possibility to control epidemic situation in each separate division owing to correction of arrangements to prophylactic of hospital-acquired infections.
Key words: hospital-acquired pneumonia, prevalence, risk-factors.

V.E. Nonikov, V.G. Novodgenov, G.B. Fedoseev, A.V. Emelianov, L.D. Sidorova, A.S. Logvinenko, A.A. Visel, I.V. Leshenko
FROMILID — CLINICAL EFFICACY IN CASES OF COMMUNITY-ACQUIRED PNEUMONIA AND EXACERBATION OF CHRONIC BRONCHITIS
// Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 30-33
Summary. In the article clinical efficacy of Fromilid in cases of community-acquired pneumonia and exacerbation of chronic bronchitis analyzed. Results evidence to high clinical efficacy of Fromilid in treatment of lower respiratory tract infections. Good clinical efficacy and safety of this antibiotic confirmed.
Key words: community-acquired pneumonia, exacerbation of chronic bronchitis, clarithromycin, Fromilid.

O.Ya. Dzyublyk, O.O. Mukhin, N.M. Nedlinska, G.B. Kapitan, V.G. Slabchenko, L.V. Chechel, R.E. Sukhin, V.Ya. Klyagin, O. J. Byalyk,M.G. Sobko, T.N. Engalicheva
EFFICACY OF AMOXICILLIN/CLAVULANIC ACID IN TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 34-38
Summary. As a result of conducted study the following conclusion was received — using of amoxicillin/clavulanic acid tablets (625 mg three times a day during 7 days) is high effective in treatment of patients with I type of infect exacerbation of chronic obstructive pulmonary diseases on the II stage.
Key words: chronic obstructive pulmonary disease, chronic obstructive bronchitis, infect exacerbations, antibacterial therapy, protected aminopenicillins, amoxicillin/clavulanic acid, AUGMENTIN.

E.M. Rekalova
DISTINCTIVE FEATURES OF PNEUMOCYSTIS CARINII INFECTION AT ADULT IMMUNOCOMPETENT PATIENTS WITH CHRONIC PULMONARY DISEASES // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 39-44
Summary. To study factors influencing on presence of P. carinii in sputum, examination of 173 patients with exacerbation and in stage of beginning remission of chronic pulmonary diseases was performed with clinical, microbiological, cytological and immunological methods. It was determined the condition of temporary and lingering P. carinii persistence (colonization of low expiratory tract). There was the correlation between quantity of P. carinii in sputum and insufficiency of phagocytes. P. carinii persistence may reduce after traditional treatment of exacerbation of chronic pulmonary diseases.
Key words: Pneumocystis carinii, chronic pulmonary diseases, chronic bronchitis, bronchial asthma, immune system, phagocytes.

R.E. Sukhin, O.Ya. Dzyublyk, O.O. Mukhin, G.B. Kapitan, N.M. Nedlinska, I.V. Dzyublyk, I.F. Samborska, S.S. Simonov, E.O. Fastova, Ya.Yu. Macheret
SPECTRUM AND SUSCEPTIBILITY OF PATHOGENS TO ANTIBACTERIALS IN NON-HOSPITALIZED CASES OF MILD TO MODERATE COMMUNITY-ACQUIRED PNEUMONIA // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 45-50
Summary. In cases of mild to moderate community-acquired pneumonia, who treated without hospitalization, S. pneumoniae stay a major pathogen (more than in 50% of cases) and keep high level of susceptibility to b-lactams and macrolids (more than 90%). In this casesvariable weight of atypical pathogens (M. pneumoniae and C. pneumoniae) was more than 20%.
Key words: community-acquired pneumonia, pathogens, susceptibility to antibacterials.

S.V. Zaykov, L.M. Kirichenko
THE DRUG ALLERGY IN CHILDREN WITH INFECTING BY MYCOBACTERIUM TUBERCULOSIS // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 51-54
Summary. Some aspects of drug allergy in children infecting by mycobacterium tuberculosis are given. The rate of drug allergy in these cases makes up 2,7% and tends to further increase. A list of the drugs more frequently causing allergic reactions was cite. In antituberculosis institutions it seems necessary to organize proper prophylaxis, diagnosis and treatment of drug allergies that would meet modern requirements.
Key words: infecting by mycobacterium tuberculosis, drug allergy, prophylaxis, diagnosis, treatment.

N.A. Litvinenko, V.M. Petrenko
LUNG TUBERCULOSIS AND WITH MORE THEN ONE CAVERN DEPENDING ON SIZE OF CAVERN AND INTENSIVE OF CEMOTHERAPY // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 55-60
Summary. In this article dates about the treating efficacy of patients with newly detected sputum positive lung tuberculosis with more then one cavern depending on size of cavern and intensive of chemotherapy were cited: with using 4 antituberculous drugs and with caverns less 4 cm (first group) or with using 5 antituberculous drugs and with caverns less 4 cm (second group); with using 4 antituberculous drugs and with caverns 4 and more cm (third group) or with using 5 antituberculous drugs and with caverns 4 and more cm (forth group). It has been established that: sputum conversion in 93,2±3,3% or in 100% patients of the first or second groups, in 59,1±10,7% or in 88,2±8,1%% patients of the third or forth groups. Caverns healing on the lung in 69,5±5,9% or in 86,7±6,2% patients of the first or second groups; in 22,7±9,1% and in 29,4±11,4% patients of the third or forth groups.
Key words: regimes of antituberculous chemotherapy, more then one cavern, size of caverns, tuberculosis intoxication, sputum conversion, caverns healing in the lung.

L.V. Gaevaya, A.I. Barbova, P. S. Trofimova, L.S. Bobkova, A.V. Chubenko
THE TREATING EFFICACY OF PATIENTS WITH NEWLY DETECTED SPUTUM POSITIVE DETERMINATION OF THE OPTIMUM RATIO OF ISONIAZID AND VITAMIN B6 FOR TREATMENT OF GUINEA-PIGS IN CONDITIONS OF EXPERIMENTAL TUBERCULOSIS // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 61-64
Summary. With the help of specially planned factorial experiment — treatment of guinea-pigs with an experimental tuberculosis by various dozes of isoniazid and vitamin B6, the mathematical model which describes this process is constructed. Severity of tuberculosis value by index of affection of internal organs of guinea-pigs. As factors which influence on index of affection were used: isoniazid as a first factor and vitamin В6 as a the second factor. Each factor was studied at three levels of doses. On the basis of the constructed mathematical model the optimum ratio between dozes of isoniazid and vitamin В6 which average 10 and 26 mg/kg has been determined.
Key words: tuberculosis, M. tuberculosis, isoniazid, vitamin B6.

I.I. Lapchynska, A.Ye. Gromova, M.M. Кoval
LEVOFLOXACIN EFFECTIVENESS IN TREATMENT OF PATIENTS WITH RELAPSE OF CHRONIC PYELONEPHRITIS // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 65-68
Summary. The results of conducted study evidenced that application of levofloxacin in dose 250 mg per day durin 10 days in complex treatment of patients with relapse of chronic pyelonephritis increases the effectiveness of treatment, has no adverse reactions and deteriorates the antibioticoresistance of ethiologic agents development.
Key words: chronіc pyelonephritis, ftorquinolones, levofloxacin, leukocyturia, bacteriuria.

A.A. Litvinenko, А.P. Каbаn, L.M. Gunina, B.V. Sorokina, I.V. Egorova, Yu.A. Zhukova, L.A. Leshuk, A.A. Litvinenko jun.
CERULOPLASMIN IN PROPHYLAXIS OF ADVERSE EVENTS PROVOCATED BY COMPLEX TREATMENT IN ONCOLOGICAL PATIENTS // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 69-72
Summary. Results of conducted study shows, that including of ceruloplasmin as accompaniment medication in a complex therapy of oncologic patients lead to reduction of endogenous intoxication and anemia, as well as the improvement of direct results of treatment.
Key words: liver carcinoma, rectal cancer, chemotherapy, operation, endogenous intoxication, lipid peroxidation, anemia, ceruloplasmin.

V.S. Ivankova, G.O. Kurilo, G.M. Shevchenko, T.V. Udatova, G.L. GorelinaEFFICACY OF COMBINED RADIOTHERAPY ON THE BACKGROUND OF RADIOMODIFICATION WITH METHOTREXATE AND FLUOROURACIL FOR TREATMENT OF LOCALLY ADVANCED CERVICAL CANCER // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 72-75
Summary. 56 patients with squamous cell cervical carcinoma were treated by chemoradiotherapy (CRT) or radiotherapy (RT) alone in the department of radiotherapy Institute of oncology AMS of Ukraine. The RT regimen were the similar at all cases. 26 women were treated by radiotherapy with lymphotropic аdministration of methotrexate and fluoruoracil infusions. These data showed good patient tolerance and encouraging response to RT combined with chemotherapy.
Key words: locally advanced cervical carcinoma, chemoradiotherapy, methotrexate, fluorouracil.

O. Ponomareva, O. Bondarouk, N. Ogorodnikova, T. Dekhtjar
EFFICACY OF CAPECITABINE IN THE MANAGEMENT OF DIFFERENT TYPE OF ADENOCARCINOMA // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 76-82
Summary. The efficacy and safety profile of full-dose capecitabine were provided during the treatment of 46 patients with different type of disseminated adenocarcinomas — breast cancer, colorectal cancer, gastric cancer, renal cancer. Our results demonstrated high efficacy and low toxicity of capecitabine as monotherapy for lung and hepatic metastases.
Key words: different type of adenocarcinoma, efficacy of treatment, capecitabine.

S.V. Zemskov
EFFICACY OF ADJUVANT TREATMENT WITH COMBINATION OF UKRAIN (NSC-631570) AND GEMCITABIN IN CASES OF PANCREAS CANCER // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 83-86
Resume. The purpose of this study was to evaluate the survival in 23 pancreatic head cancer patients after curative pancreaticoduodenal resection treated by combination of Ukrain and gemcitabin. The 2 year OS and PFS were 60% and 20% respectively in 15 patients (main group) treated by combination of Ukrain and gemcitabin. In 8 patients of untreated control group there were no 2-year survivors. The difference in OS was statistically significant. The median survival was 32 months in main group vs 10 months in control. Application of the combination of Ukrain and gemcitabin is effective in adjuvant treatment of patients with pancreas cancer.
Key words: pancreatic cancer, pancreatoduodenal resection, Ukrain, gemcitabin.

V.L. Kobys, G.I. Klymnyuk, O.V. Shaida, V.M. Zhukova, V.M. Nechval, O.E. Lotoreva
USE OF METHOTREXATE IN HIGH DOSES FOR THE TREATMENT OF CHILDREN WITH MALIGNANT BONE NEOPLASMS // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 87-89
Summary. 38 children aged 8–16 years received methotrexate in a dose of 12 g/m2 in complex therapy of malignant bone neoplasms. According to the data of biochemical analyzer TDX-FLX, by means of immunofluorescence method, the observation of preparation level in blood serum and the prescription of sufficient doses of calcium folinate were daily performed. There were no cases of death. The complications in form of skin reactions, hepatotoxicity lst–4th degree, delay of methotrexate elimination, moderately pronounced gastrointestinal and myelosuppressive effects were observed. The obtained results suggest a good tolerance of the preparation and its safety under condition of apparatus monitoring of its elimination, ensuring of a sufficient diuresis level, urine alkalization and prescription of calcium folinat in sufficient dose and for sufficient time.
Key words: osteogenic sarcoma, malignant giant-cell tumor, Ewing's sarcoma, methotrexate, toxicity.

L.I. Vorobieva, N.P. Cip
USING OF ONDASETRON FOR PROPHYLAXIS of NAUSEA AND VOMITTING DURING HIGHLY EMETOGENIC COMBINE POLYCHEMOTHERAPY IN PATIENTS WITH HIGH RISK OF POSTMOLAR TROPHOBLASTIC TUMORS // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 90-94
Summary. Ondansetron (Osetron, Dr. Reddy's) was used for the treatment of nausea and vomiting during 56 blocks of highly emetogenic combine polychemotherapy in 14 patients with high risk of postmolar trophoblastic tumors. Acute and delayed vomiting wasn't registered. Acute nausea occurred in 7,1% of cases, delayed nausea — in 14,3% cases.
Key words: postmolar trophoblastic tumors, polychemotherapy, polychemotherapy.

Yu.I. Feshenko, A.Ya. Dzyublyk, T.A. Pertceva, G.B. Kapitan, N.N. Nedlinskaya, A.A. Mukhin, V.G. Slabchenko, R.E. Sukhin, V.Ya. Klyahin, S.S. Simonov, S.N. Prokopchuk, M.O. Moskvichev, V.V. Lodgkin, R.A. Bontcevich
ADULT PATIENTS WITH HOSPITAL-ACQUIRED PNEUMONIA: DIAGNOSTICS, TREATMENT AND PROPHYLAXIS (guideline) // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 95-112
Summary. Proposed guidline didicated to actual problem of pulmonology — hospital-acquired pneumonia (HAP). Guidline based on modern scientific researches of domestic and foreing researchers. Determinations of HAP, modern epidemiological dates, death-rate and indexe of lethality were cited. Questions about ethiology, pathogenesis and diagnostics covered in greater details. Modern approachments to treatment of patients with HAP eludicated in guideline. Placed high emphasis on rational using of antibacterials. Expanded criteria of efficacy of treatment and scheme of treatment of patients with HAP depending on peculiarities of its course, that allow to unify requirements to medical care in case of HAP and to raise efficacy of their treatment in multifield hospital.
Key words: hospital-acquired pneumonia, diagnostic, treatment, antibacterials.

V.М. Меlnik, Т.А. Аlexandrina, C.А. Cherenko
PROPHILAXIS, DIAGNOSTICS AND TRATMENT OF TUBERCULOSIS WITHAIDS/HIV // Ukr. J. Chemotherapy.- 2005.- N1-2.- P. 113-118
Summary. In the article peculiarities of prophylaxis, diagnostics and treatment of patients with tuberculosis and HIV, schemes of their prophylaxis, diagnostics and treatment presented.
Key words: tuberculosis, AIDS, HIV-infection, etiotropic treatment, diagnostics, phrophilaxis.

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