Ukrainian Journal of Chemotherapy.- 2001.- № 3.
Abstracts

Contents

Some aspects of antibacterial sequential therapy of community-acquired pneumonia and the associated role of "respiratory" fluoroquinolone levofloxacin
Yu.M. Mostovoy
The advantages of antibacterial sequential therapy of community-acquired pneumonia in comparison with conventional parenteral antibacterial therapy have been summarized. The novel "respiratory" fluoroquinolone levofloxacin have been characterized by high clinical and microbiological efficacy.
Key words: antibacterial sequential therapy, community-acquired pneumonia, levofloxacin.
Yu.M. Mostovoy Some aspects of antibacterial sequential therapy of community-acquired pneumonia and the associated role of "respiratory" fluoroquinolone levofloxacin // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 3 - 7

Modern treatment options in patients with metastatic liver tumors
S.O. Shalimov, O.O. Lytvinenko, S.A. Lyalkin, O.O. Lytvinenko
We analyzed the literature data regarding current treatment options for secondary malignant hepatic neoplasms. Surgical resection remains the most effective method, however, only small percent of patients with liver metastases are estimated to be candidates for resection. Hepatic cryosurgery and transcatheter arterial chemoembolization are characterized by promising results regarding survival and may improve the outcome in suitable patients.
Key words: metastatic liver tumors, treatment options.
S.O. Shalimov, O.O. Lytvinenko, S.A. Lyalkin, O.O. Lytvinenko Modern treatment options in patients with metastatic liver tumors // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 8 - 12

Application of minimal doses of the drugs in oncology
G.P. Potebnia, G.S. Lisovenko, A.A. Litvinenko, V.G. Lisovenko
Literature review deals with the analysis of efficacy of minimal and sub-minimal doses of drugs and biologically active combinations, first of all anticancer compounds. The data regarding an administration of minimal doses of cytostatics and immunomodulators were studied. The conclusions about perspectives of that kind of studies for development of new compounds and methods of application of drugs were stated.
Key words: sub-minimal doses, drugs, cytostatic, antitumor therapy, experiment.
G.P. Potebnia, G.S. Lisovenko, A.A. Litvinenko, V.G. Lisovenko Application of minimal doses of the drugs in oncology // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 13 - 19

The ways of improvement of diagnostics of drug allergy during the chemotherapy
B.M. Puhlik, D.I. Zabolotny, S.M. Puhlik, M.A. Tkhorovsky, V.B. Rusanova, L.B. Zabrodska
Drug allergy remains an urgent problem because of its high prevalence in population, especially in subjects often requiring long treatment courses. Three-staged procedure should be applied for timely diagnosis of drug allergy in medical institutions: 1st - profound study of medical history and administration of modified skin tests; 2nd - application of nasal allergen challenge; 3rd - complex laboratory examination. 
Key words: drug allergy, diagnostics, nasal allergen challenge, skin tests.
The ways of improvement of diagnostics of drug allergy during the chemotherapy
Puhlik B.M., Zabolotny D.I., Puhlik S.M. et al. // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 20 - 26

The efficacy of moxifloxacin in infectious exacerbations of chronic obstructive bronchitis
A.Yа. Dzyublik, N.G. Gorovenko, A.A. Muhin, I.A. Shlapa, V.V. Dyachenko, M.G. Sobko, O.O. Fastova
The results of the study allowed suggesting oral moxifloxacin (400 mg once daily for 5 days) as highly effective medication in treatment of I type of infectious exacerbation in chronic obstructive bronchitis patients.
Key words: chronic obstructive bronchitis, infectious exacerbations, antibacterial therapy, fluoroquinolones, moxifloxacin.
The efficacy of moxifloxacin in infectious exacerbations of chronic obstructive bronchitis /   Dzyublik A.Yа., Gorovenko N.G., Muhin A.A. // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 27 - 30

Dynamics of parameters of surfactant homeostasis and microcirculation in patients with chronic obstructive bronchitis, undergoing differentiated therapy
R.V. Razumniy
Peculiarities of clinical course, endoscopic changes, dynamics of tensiometry and rheology parameters of serum and systemic changes of microcirculation were studied in 62 patients with chronic obstructive bronchitis. The conventional therapy was administered to 31 patient, the rest of the patients received the inductor of endogenous interferon - cycloferon. Positive outcomes of the disease registered in all patients, however more expressed clinical effect was noted cycloferon group. The application of the inductor of endogenous interferon promoted more favorable clinical course of disease, improvement of bronchial drainage function, more significant reduction of obstructive syndrome and decrease of severity of endobronchitis. The rate of improvement of parameters of the dynamic interphase tensiometry and rheology of serum, the system parameters of microcirculation in cycloferon group of patients exceeded the similar parameters in conventionally treated patients. 
Keywords: chronic obstructive bronchitis, dynamic surface tensiometry, microcirculation, treatment, cycloferon.
R.V. Razumniy Dynamics of parameters of surfactant homeostasis and microcirculation in patients with chronic obstructive bronchitis, undergoing differentiated therapy // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 31 - 36

Antibiotics resistance of enterococci strains, isolated from newborns with perinatal diseases
L.V. Avdeeva, O.I. Polyshchuk, O.S. Makushenko, M.B. Kanibolotska
There was studied a susceptibility to ampicillin, chloramphenicol, tetracylin, nitrofurantoin, ciprofloxacin, gentamycin, imipenem and vancomycin of 30 strains of E. faecalis and 20 strains of E. fecium, isolated from the feaces of the newborns with perinatal diseases during January-June 2001, who had been hospitalized to intensive care departament of neonatalogical hospital.
There was revealed a high level and multiplicity of resistance of isolated from hospitalized patients enterococci. There were no significant differences in resistance pattern between E. faecalis and E. fecium. None of the isolates was vancomycin-resistant. Based on study resuts one could consider the hospital genesis of strains, colonizing the newborn bowel. The necessity of microbiological monitoring and approaches to administration of antibiotics for treatment of enterococcal infections in specific hospital were substanciated.
Key words: newborns with perinatal diseases, enterococci, antibiotics resistance.
L.V. Avdeeva, O.I. Polyshchuk, O.S. Makushenko, M.B. Kanibolotska Antibiotics resistance of enterococci strains, isolated from newborns with perinatal diseases // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 37 - 40

Effect of atp-long on erythrocyte cellular membranes in chemotherapy of the patients with locally advanced gastric cancer
L.M. Gunina, L.S. Mkhitaryan, О.О. Litvinenko, V.B. Korobko, N.I. Muzyka
The effect of ATP-LONG on metabolic processes and structural and functional status of erythrocyte membranes in intraarterial polychemocherapy of the patients with locally advanced gastric cancer has been studied. It has been revealed that this medication had significant membrane stabilizing effect and promoted a decrease of toxicity of chemotherapy.
Key words: locally advanced gastric cancer, intraarterial polychemotherapy, ATP-LONG, erythrocyte membranes.
Effect of atp-long on erythrocyte cellular membranes in chemotherapy of the patients with locally advanced gastric cancer / Gunina L.M., Mkhitaryan L.S., Litvinenko О.О. // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 41 - 43

A comparative evaluation of efficacy of antral and amizon in viral hepatitis patients
A.F. Frolov, V.M. Frolov, V.O. Tereshin
The results of the study have demonstrated that combined therapy with antral and amizon was highly effective in viral hepatitis patients and allowed to prevent an exacerbation in patients with chronic hepatitis.
Key words: viral hepatitis, chronic hepatitis, amizon, antral.
A.F. Frolov, V.M. Frolov, V.O. Tereshin A comparative evaluation of efficacy of antral and amizon in viral hepatitis patients // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 44 - 50

Clindamycin in treatment of purulent inflammatory diseases
A.S. Chemerkin, I.S. Zaritska, N.N. Mogilevska
The results of this clinical trial confirm high clinical efficacy of oral clindamycin in dosages 150-300 mg 4 times daily for 5-14 days in patients with paratonsillitis, paratonsillar abscess, chronic purulent maxillary sinusitis and exacerbation of purulent otitis media.
Key words: paratonsillitis, paratonsillar abscess, chronic purulent maxillary sinusitis and exacerbation of purulent otitis media.
A.S. Chemerkin, I.S. Zaritska, N.N. Mogilevska Clindamycin in treatment of purulent inflammatory diseases // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 51 - 53

Community-acquired pneumonia in adults: etiology, pathogenesis, classification, diagnostics, antibacterial therapy (methodiсal recommendations)
Yu.I. Feshchenko, O.Ya. Dzyublik, V.P. Melnik, N.G. Gorovenko, N.M. Nedlinskaya, O.O. Muhin, V.G. Slabchenko, G.B. Kapitan, S.S. Simonov, V.V. Dyachenko, M.O. Moskvichev
The methodical recommendations are devoted to the relevant problem of respiratory medicine - community-acquired pneumonia in adults. The up-to-date definition of pneumonia, epidemiological data regarding its prevalence, mortality and lethality have been presented. The etiology, pathogenesis and diagnostics of the disease have been characterized. There have been described the modern approaches in treatment of community-acquired pneumonia. A special emphasis has been put on the rational administration of the antibiotics. The authors have summarized the data regarding novel antibacterial medications and treatment regimens. The effectiveness of therapy evaluation criteria and examples of formulation of community-acquired pneumonia diagnosis have been stated. 
Key words: community-acquired pneumonia, diagnostics, treatment, antibacterial medications. 
Community-acquired pneumonia in adults: etiology, pathogenesis, classification, diagnostics, antibacterial therapy (methodiсal recommendations) / Feshchenko Yu.I., Dzyublik O.Ya., Melnik V.P. // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 54 - 64

Vaccine prophylaxis of influenza 
I.V. Dzyublik
The aspects of epidemiological situation on influenza in Ukraine for 2000/2001 and 2001/2002 seasons, as well as modern data regarding influenza virus morphology and antigen variability were presented. Available influenza vaccines were characterized. The risk groups for immunization in children, adolescents and adults were allocated. The peculiarities of immune response, adverse reactions, epidemiological and immunological effectiveness of attenuated vaccines were determined.
Key words: influenza virus, influenza vaccines, immunity, adverse reactions, effectiveness, reactogenicity, antiviral medications.
I.V. Dzyublik Vaccine prophylaxis of influenza // Ukr. J. Chemotherapy.- 2001.- N 3.- P. 65 - 72

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